Carlos Alazraqui

Winslow (voice)

Jim Cummings

Cat (voice)

Tom Kenny

Dog / Cliff (voice)

Jane Krakowski

CatDog's Mother / Pussycat Catfield (voice)

Dwight Schultz

Eddie (voice)

Billy Bob Thornton

Hound Dog McDog / CatDog's Step-father (voice)

Frank Welker

Bessie the Sea Monster (voice)

Maria Bamford

Shriek Dubois (voice)

Billy West

Rancid Rabbit (voice)

Nika Futterman

Lola (voice)