Frank Welker

Scooby-Doo / Fred Jones (voice)

Grey DeLisle

Daphne Blake (voice)

Matthew Lillard

Shaggy Rogers (voice)

Kate Micucci

Velma Dinkley (voice)

Cassandra Peterson

Elvira, Mistress of the Dark (voice)

Bill Nye

Bill Nye (voice)

Dwight Schultz

Dr. Crane, AKA: Scarecrow (voice)

Bumper Robinson

Mike (voice)

Roger Craig Smith

Autopilot / Parent (voice)

Fred Tatasciore

Alpha Jackal-Lantern / Federal Agent Malarkey (voice)

David Herman

Sheriff, AKA: Cutler Toe (voice)