Tom Waits

The Narrator (voice)

Jimmi Simpson

Detective David Mills (voice)

Da'Vine Joy Randolph

Detective Gail Johnson (voice)

John C. Reilly

Donovan Smith (voice)

Bebe Neuwirth

Lady Andrea The Giant (voice)

Jason Mantzoukas

Tim Snodgrass (voice)

Damon Herriman

Street Hustler Boy (voice)

Melissa Villaseñor

Sister Mary Margaret (voice)

Kurtwood Smith

Carpenter K. Smith (voice)

Tim Heidecker

Mayor Kevin De Maximum (voice)

Chris Conrad

Detective Nico Onasis (voice)

Hana Mae Lee

Christina Smalls (voice)

Alia Shawkat

Little Grace (voice)

Julian Barratt

The Most Dangerous Man in the World (voice)

Kristen Bell

Donella Pecker (voice)

Luis Guzmán

Rodrigo Smalls (voice)

Sunita Mani

Detective Jaya Mukherjee (voice)

Caleb McLaughlin

Trevor Johnson (voice)

Tim Meadows

Jeff Thumb (voice)

Terry O'Quinn

Captain Krieger (voice)