Antonio Banderas

Puss in Boots (voice)

Salma Hayek Pinault

Kitty Softpaws (voice)

Zach Galifianakis

Humpty Dumpty (voice)

Billy Bob Thornton

Jack (voice)

Amy Sedaris

Jill (voice)

Constance Marie

Imelda (voice)

Mike Mitchell

Andy Beanstalk (voice)

Guillermo del Toro

Comandante / Hombre del bigote (voice)

Conrad Vernon

Raoul / Soldier (voice)

Chris Miller

Little Boy Blue / Friar Miller / Prison Guard / Manuel / Rafael (voice)

Tom Wheeler

Bartender / Mean Boy / Wagon Driver / Hotel Owner / Rodrigo (voice)

Tom McGrath

Bar Thief (voice)

Bob Joles

Giuseppe (voice)

Latifa Ouaou

Crazy Woman / Mean Girl / Milk Lady / Little Boy (voice)

Jessica Schulte

Estella Maria (voice)

Bob Persichetti

Ohhh Cat (voice)

Nina Barry

Ivana / Charo (voice)

Sergio Bruna

Soldier (voice) (uncredited)

Rebecca Davis

Various Cats (voice) (uncredited)

Joshua Rush

Additional Voices (voice) (uncredited)