Steve Carell

Gru (voice)

Jason Segel

Vector (voice)

Miranda Cosgrove

Margo (voice)

Elsie Fisher

Agnes (voice)

Dana Gaier

Edith (voice)

Russell Brand

Dr. Nefario (voice)

Julie Andrews

Gru's Mother (voice)

Will Arnett

Mr. Perkins (voice)

Kristen Wiig

Miss Hattie (voice)

Pierre Coffin

Tim / Bob / Mark / Phil / Stuart (voice)

Chris Renaud

Dave (voice)

Jemaine Clement

Jerry (voice)

Jack McBrayer

Carnival Barker / Tourist Dad (voice)

Danny McBride

Fred McDade (voice)

Mindy Kaling

Tourist Mom (voice)

Rob Huebel

Anchorman (voice)

Ken Daurio

Egyptian Guard (voice)

Ken Jeong

Talk Show Host (voice)

Katie Leigh

Additional Voices (voice)

Ranjani Brow

Additional Voices (voice)