Steve Carell

Gru / Dru (voice)

Kristen Wiig

Lucy Wilde (voice)

Trey Parker

Balthazar Bratt (voice)

Miranda Cosgrove

Margo (voice)

Dana Gaier

Edith (voice)

Nhev Scharrel

Agnes (voice)

Pierre Coffin

Mel / Minions / Museum Director / Additional Voices (voice)

Steve Coogan

Fritz / Silas Ramsbottom (voice)

Julie Andrews

Gru’s Mom (voice)

Jenny Slate

Valerie Da Vinci (voice)

Michael Beattie

Scar-Faced Man / TMZ Announcer (voice)

Andy Nyman

Clive the Robot (voice)

Adrian Ciscato

Niko (voice)

Brian T. Delaney

Commercial Announcer / Military Officer / Additional Voice (voice)

Ken Daurio

Celebrity (voice)

Cory Walls

Vincenzo (voice)

Lori Alan

Additional Voices (voice)

Carlos Alazraqui

Additional Voices (voice)

Kyle Balda

Additional Voices (voice)

Bob Bergen

Additional Voices (voice)