Sandra Bullock

Scarlet Overkill (voice)

Jon Hamm

Herb Overkill (voice)

Michael Keaton

Walter Nelson (voice)

Allison Janney

Madge Nelson (voice)

Steve Coogan

Professor Flux / Tower Guard (voice)

Jennifer Saunders

Reine Elizabeth II (voice)

Geoffrey Rush

Narrator (voice)

Steve Carell

Gru (voice)

Pierre Coffin

Kevin / Stuart / Bob / The Minions (voice)

Katy Mixon

Tina (voice)

Michael Beattie

VNC Announcer / Walter Jr. (voice)

Hiroyuki Sanada

Sumo (voice)

Dave Rosenbaum

Fabrice (voice)

Paul Thornley

News Reporter (voice)

Kyle Balda

Additional Voices (voice)

Ava Acres

Additional Voices (voice)

Sherry Lynn

Additional Voices (voice)

Mickie McGowan

Additional Voices (voice)

Carlos Alazraqui

Additional Voices (voice)

Lori Alan

Additional Voices (voice)